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The biological activities of famesoic acid derivatives against pathogenic fungi and bacteria were investigated. Famesoic acid and its derivatives showed growth inhibitory activities against various bacteria. Among the compounds tested, geranylgeranoic acid (3) had potent antibacterial activity against Salmonella typhimurium, Proteus vulgaris, and Bacillus subtilis with minimum inhibitory concentration (MIC) in the range of 6.25-12.5 ㎍/ml. On the other hand, amide derivatives of famesoic acid showed some antifungal activities. In particular, 3, 7, 11-trimethyl-dodeca-2, 6, 10-trienoic acid amide (5a) had a potent antifungal activity against Aspergillus niger, Candida albicans, and Trichophyton sp. with MIC in the range of 6.25-25 ㎍/ml.
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